Lung injury – Communicable Diseases Research

Major royal jelly proteins elicited suppression of SARS-CoV-2 entry and replication with halting lung injury

Article

Published on 2023-02-152023-07-11
Journal: International journal of biological macromolecules
[Category] COVID19(2023년),

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

[키워드] Activation acute lung injury ALI model alleviate Analysis analysis attenuate Baidu caused Cell cellular China component Component analysis components Compound COVID-19 COVID-19 patients demonstrated experiment experimental validation Formula in vivo increases in indicated Inflammation ingredient inhibited inhibiting Kyoto lung Lung injury material mechanism of action Mild molecular mechanism network network pharmacology NF-κB pathway NF-κB signaling NF-κB signaling pathway Obstructive Ontology p-NF-κB p65 pathway pharmacological predicted proinflammatory Proteins reduced syndrome target treat Treatment Xuanfei baidu formula.
[DOI] 10.1016/j.jep.2022.115833 PMC 바로가기

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

[키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α Toll-like receptor 4. treated Treatment were assessed were measured
[DOI] 10.1016/j.jep.2022.115763 PMC 바로가기

COVID-19: imbalanced cell-mediated immune response drives to immunopathology

Article

Published on 2022-12-012022-11-15
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathogenesis. pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection
[DOI] 10.1080/22221751.2022.2122579 PMC 바로가기

Saliva as a Potential Specimen to Monitor IL-6, TNF-α and IL-10 in COVID-19 Patients

Article

Published on 2022-12-012022-11-15
Journal: Inflammation
[Category] COVID19(2023년), SARS, 치료기술,

Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2

Article

Published on 2022-12-012022-11-16
Journal: Biochemical Genetics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website
[DOI] 10.1007/s10528-022-10206-7 PMC 바로가기

Using host receptor as a decoy to treat COVID-19: a solution for immune escape?

Article

Published on 2022-11-082022-11-16
Journal: EMBO Molecular Medicine
[Category] COVID19(2023년), SARS, 변종,

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2

Article

Published on 2022-11-082022-11-15
Journal: EMBO Molecular Medicine
[Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 Administered administration ameliorated Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody betacoronaviruses bind catalytic activity catalytically active Clinical use COVID-19 decoy demonstrated effective entry receptor High dose Host increased survival Infection Inflammation inoculated intravenous intravenously K18-hACE2 mice Loss Lung injury mechanism neutralization potency neutralize omicron Omicron variant persist PROTECT receptor receptor. reduced sACE2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown substrate target the SARS-CoV-2 therapeutic efficacy therapeutic potential Treatment virus
[DOI] 10.15252/emmm.202216109 PMC 바로가기

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice

Article

Published on 2022-11-012022-11-15
Journal: Inflammation research : official journal of the Eu
[Category] 유전자 메커니즘, 진단,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics proteomics. Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α
[DOI] 10.1007/s00011-022-01623-w PMC 바로가기

Integrating in silico and in vivo approach for investigating the role of polyherbal oil in prevention and treatment of COVID-19 infection

Article

Published on 2022-11-012022-11-15
Journal: Chemico-biological interactions
[Category] SARS, 변종, 치료제,

[키워드] ACE2 Analysis angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory activity antiviral drug approach approved combating Compound contribute Control COVID-19 COVID-19 infection COVID-19 patients cytokine Efficacy ELIXIR entry of SARS-CoV-2 expression FDA GC-MS group groups hamster hamsters human host in silico in vivo in-silico Infection inhibiting inhibitory effect investigated Lung injury male membrane molecular docking molecular docking studies new SARS-CoV-2 PCR Polyherbal oil Prophylactic Protective real time receptor reduced respiratory diseases SARS-CoV-2 selected significantly Spike protein the SARS-CoV-2 Therapeutics Therapeutics. these compound treat Treatment treatment groups Vaccine variants viral envelope Viral load
[DOI] 10.1016/j.cbi.2022.110179 PMC 바로가기